Two sample MR report
HLA-DQA2_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 54 | -0.1187454 | 0.0523102 | 0.0273789 |
| Weighted median | 54 | 0.0306493 | 0.0088554 | 0.0005380 |
| Inverse variance weighted | 54 | 0.0416821 | 0.0064649 | 0.0000000 |
| Simple mode | 54 | 0.0153437 | 0.0221728 | 0.4919547 |
| Weighted mode | 54 | 0.0159027 | 0.0195255 | 0.4190268 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 25.33836 | 52 | 0.9993264 |
| Inverse variance weighted | 34.88983 | 53 | 0.9741319 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1164478 | 0.0376787 | 0.0032066 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009312 | 0 | TRUE | 0.003841 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
